Team Lead – Protein Biology – Thermo Fisher Scientific, Bangalore

Job Description

About Team: Antibody team
The antibody team is involved in engineering and development of antibodies, with a deep focus on reagent quality and specificity. The core activities of the team include design, development, purification, conjugation and testing of antibodies in a variety of immunoassay applications using pioneering tools and technologies. The goal of the program is advanced product development and creation of product specific information to promote research use.
Role:
To be an integral part of an antibody development team with a focus on performance and specificity using innovative molecular, protein, and cell biology methods. The successful candidate will be joining the Bangalore R&D leadership team for developing antibodies for the Thermo Fisher Scientific Antibody portfolio. This position involves people management, internal, external and cross function collaboration to drive technical strategies for execution in R&D projects involving state-of-art methods.
Responsibilities:
Perform in a fast- paced environment towards antigen and antibody development
Lead team of scientists in matrix style operation, provide technical and operational supervision.
Drive conceptualization within teams to enable development of successful protocols for antigen design and development
Mentoring and training junior scientists in research, designing and experimental execution, interpreting data and data presentation to the stakeholders
Partner with supporting functions such as product management, program management, operations, and business development to meet program goals.
Good scientific writing skills, establishing technical protocols for effective transfer to operations teams.
Good documentation practice is a must to maintain data integrity and accuracy.
Delivering high quality results according to project schedule in support of product commercialization from concept to launch including early feasibility, development and validation phases.
Support the manufacturing team for technical support and quality by providing technical guidance.

Qualifications

• Education & Experience needed:
• Applicants should have a Master’s degree with 15+ years R&D experience or PhD with 7+ years experience in a life sciences field with a strong focus on protein biology. Minimum 3-4 years of Industrial experience is required. Prior people management experience is essential.

Skills Required

• Nature of experience:
• Strong domain expertise
• in the antibody development and engineering field including hybridoma, single B cell, and other recombinant antibody platforms
• Expert in the field of peptide and protein design, expression, purification, and protein-protein interaction (Structure -function -relationship)
• Thorough understanding of antigen/immunogen properties, design and development towards eliciting desired antibody response
• Extensive experience in expression and purification of recombinant proteins from bacterial, yeast, insect and mammalian systems
• Extensive experience in structural biology, antibody and protein engineering, computational modeling and rational design.
• Expertise in development of conjugation chemistries or performing antibody conjugations is desired
• Broad knowledge and experience in molecular biology, cell biology, immunoassays, protein design, engineering, purification, and conjugation fields to enable successful delivery on program goals
• Thorough in biochemical and immunoassay workflows such as ELISA, SDS-PAGE, Western blotting, IF, IHC
• Ability to provide technical trouble shooting to resolve scientific problems.
• Experience in authoring and optimizing standard operating procedures with a focus on reproducibility
• Skills for identifying deviations from expected outcomes, problem solving and suggesting alternatives
• Excellent written and verbal presentation skills
• Experience in leading product launches through knowledge and application of product commercialization processes including feasibility, development, and validation stages
• Proven leadership skills and ability to work alongside colleagues from different backgrounds
• Experience with leading and mentoring people with or without direct reporting structure
• Strong, independent understanding of standard and emerging research protocols and techniques are preferred
• The successful candidate will be self-motivated and a self-starter who is excellent at learning and applying new concepts for process or product improvements, possess excellent people and project leadership skills including decision making and conflict resolution, oral and written communication skills to connect to peers and leadership, and demonstrate role model leadership for integrity, intensity, innovation, and involvement.

Additional Information

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