Research Scientist II, Biochemistry – Novartis, Cambridge (MA), USA

Job Description

Are you ready to help discover new medicines for people living with cardiovascular and metabolic diseases? Join our Cardiovascular and Metabolic Disease (CVM) research team at Novartis Biomedical Research in Cambridge, Massachusetts, where your work at the bench will advance our understanding of disease biology and help turn scientific insight into transformative medicines for patients.
As a laboratory-based in vitro Research Scientist in the CVM Biochemistry unit, you will contribute to target validation, assay development, and drug profiling across exploratory and pipeline projects. You will work with several classes of therapeutic molecules, including small molecules and biologics, and collaborate closely with colleagues across the broader research organization to move our projects forward.

Key Responsibilities

• Plan and execute biochemical and cell-based assays to support drug discovery.
• Perform in vitro experiments to support assay development, profiling of therapeutic leads, target validation, and mechanism-of-action studies.
• Apply core laboratory techniques, including cell culture, quantitative polymerase chain reaction, gene knockdown with small interfering RNA, immunofluorescence microscopy, and Western blotting.
• Analyze data and document experiments accurately in the electronic laboratory notebook.
• Present results at lab and department meetings.
• Assist in writing research documents and scientific publications.

Qualifications

• Bachelor's or Master's degree in biology, biochemistry, cell biology, or a related life science field (minimum Bachelor's degree and 4+ years of relevant post-graduate research experience).
• Strong attention to detail, with the ability to quickly learn new techniques.
• Knowledge of statistics and computational data analysis.
• Strong communication and creative problem-solving skills, with the ability to work collaboratively in a matrixed team environment.
• Exemplary laboratory practices and record-keeping skills.
• Flexibility and an aptitude for learning, with a passion for driving groundbreaking science.

Skills Required

• Desirable requirements:
• Experience culturing, differentiating, and genetically engineering (via viral transduction) human induced pluripotent stem cell-derived cardiomyocytes.
• Research experience in cardiovascular or metabolic disease, such as heart failure, obesity, atrial fibrillation, or atherosclerosis.

Additional Information

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